Giorgio Brutini Mens VELVET Navy Dress Loafers 65 M iuVEwCrs5P

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Giorgio Brutini Mens VELVET Navy Dress Loafers 6.5 M iuVEwCrs5P
  • Leather
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  • Velvet upper in a dress slip-on style with a round toe
  • Stitched accent on the vamp
  • Padded tongue and collar
  • Smooth lining, cushioning insole
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Bryan Lola Live at Blumenhof Winery
Saturday, April 23, 2016 - 2:00pm to 5:00pm
Blumenhof Winery

Bryan Lola (Folk/Rock/Jazz) will perform at Blumenhof Winery in Dutzow, MO on Sunday, April 23from 2-5pm.

Tipple Hill Winery Vineyard- Music
Saturday, April 23, 2016 - 7:00pm to 9:00pm
Tipple Hill Winery Vineyard

Music by Aaron Blumer

Young Country favorite hits

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Sunday, April 24, 2016 - 2:00pm to 5:00pm
Blumenhof Winery

Downstream (Folk Trio) will perform at Blumenhof Winery in Dutzow, MO on Sunday, April 24from 2-5pm.

Wine Painting Party
Thursday, April 28, 2016 - 7:00pm to 9:00pm
Jowler Creek Winery
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Saturday, April 30, 2016 - 11:00am to Sunday, May 1, 2016 - 7:00pm
Weston Wine Company

What wines pair best with the foods at your Cinco de Mayo Fiesta? Find out with 7 bites of festive Mexican Food paired with Weston Wine Company wines for only $14/person while supplies last during our normal tasting room hours on Saturday and Sunday. The cost of the pairing also includes a logo glass you get to take home! No reservations needed, just stop by during business hours for a festive taste! (Sunday 12-5pm).

Live Music at Riverwood Winery
Saturday, April 30, 2016 - 1:00pm to 4:00pm
Riverwood Winery

Uncork from your long week outside with a glass of wine and live music with Dan Bliss.

Event URL: www.riverwoodwinery.com/events

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Saturday, April 30, 2016 - 2:00pm to 5:00pm
Red Moose Vineyard

Live music - great entertainer!

Tipple Hill Winery Vineyard- Quarter
Saturday, April 30, 2016 - 2:00pm to 5:00pm
Tipple Hill Winery Vineyard

Pre-Sales 1:30 Auction 2:00 to 5:00 p.m.

Quarter Auction Fundraiser for theCystic Fibrosis Foundation.

Mark Moebeck Live at Blumenhof Winery
Saturday, April 30, 2016 - 2:00pm to 5:00pm
Blumenhof Winery

Mark Moebeck (Classic Rock) will perform at Blumenhof Winery in Dutzow, MO on Saturday, April 30 from 2-5pm.

2 years ago
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Photo Credit: mikanaka / Finn Comfort Womens Aachen Loafer Black Patent 2i62uU

The disease goes by many names, but in America, ALS is commonly known as Lou Gehrig’s disease (after the hall of fame baseball player who contracted it). No matter what you call it, ALS is a seriously debilitating, progressive condition that destroys the lines of communication between nerves and muscles.

Since the neuromuscular system includes such a wide range of nerve cells, the damage of ALS is likewise widespread: little daily acts, both conscious and subconscious, become increasingly difficult. Not only will the body struggle with more complex motor activities like lifting objects, but even the simple act of breathing can be interrupted.

ALS is frightening and tough to comprehend, which can make a diagnosis even more difficult to handle. Understanding the disease begins with breaking down the complicated title.

A (amyotrophic): this literally translates to “no muscle nourishment.” As the muscles lose nourishment, they become weaker, and muscle strength in every region of the body begins to suffer as the muscles waste away.

A (amyotrophic):

L (lateral): refers to the sides of the spinal cord, where the disease attacks the nerves that feed and control the muscles around the body.

L (lateral):

S (sclerosis): scar tissue that develops in the place of healthy tissue. In this case, the damaged nerves at the sides of the spinal cord give way to hardened tissue, which stops the nerve signals from traveling to the muscles.

S (sclerosis):

In the end, the nerve damage, scar tissue, and muscle wasting lead to paralysis of the body, by severing the neuron pathways between the brain, spinal cord, and the muscles. But even though neurons in the brain do suffer, the physical senses and mental comprehension are not necessarily affected.

The damage occurs in the upper and lower motor neurons, which are nerve cells in the brain and spinal cord that command muscle movement, but are not in charge of other sensations like hot and cold, pain, pressure, or emotional response. One of the most tragic elements of ALS is the mind often continues to function well but the body just won’t respond, and so expression and communication becomes frustratingly difficult.

ALS is a fairly rare disease — it only affects about three in every 100,000 people each year. Given that it’s relatively uncommon, it mimics other diseases, and is difficult to predict, there is also a good deal of mystery involved.

However, experts have uncovered some facts that can help to determine ALS risk and help spot the first symptoms.

Theoretically, anyone could develop ALS, but it typically manifests in adults between the ages of 40 and 70. Some of these adults will develop symptoms quickly, while others begin to show signs that worsen gradually.